Amazon SimpleDB is a web service for running queries on structured data in real time. This service works in close conjunction with Amazon Simple Storage Service (Amazon S3) and Amazon Elastic Compute Cloud (Amazon EC2), collectively providing the ability to store, process and query data sets in the cloud. These services are designed to make web-scale computing easier and more cost-effective for developers.
Traditionally, this type of functionality has been accomplished with a clustered relational database that requires a sizable upfront investment, brings more complexity than is typically needed, and often requires a DBA to maintain and administer. In contrast, Amazon SimpleDB is easy to use and provides the core functionality of a database - real-time lookup and simple querying of structured data - without the operational complexity. Amazon SimpleDB requires no schema, automatically indexes your data and provides a simple API for storage and access. This eliminates the administrative burden of data modeling, index maintenance, and performance tuning. Developers gain access to this functionality within Amazon's proven computing environment, are able to scale instantly, and pay only for what they use.
If we were just starting out in business I might be tempted to use Amazon for everything. I'm amazed that Microsoft doesn't seem to be responding for all the trumpeting of its Live initiatives.